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All Journal Journal of Pharmaceutical and Sciences.
Rosi Kustiani
Universitas Al Ghifari
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulasi dan Uji Aktivitas Gel Antisariawan Ekstrak Daun Alpukat (Persea americana Mill.) Secara In vivo Pada Tikus Putih Taufik Septiyan Hidayat; Rosi Kustiani; Gioamanda Dwi Sumarni
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1688

Abstract

Oral ulceration is a common disorder that causes pain and can interfere with daily activities. Avocado (Persea americana Mill.) leaves contain bioactive compounds that may support wound healing. This study optimized a gel formulation containing avocado leaf extract and evaluated its anti-ulcer activity in male Wistar rats. The extract was prepared by maceration with 96% ethanol and formulated into carbopol-based gels. Twenty-four rats were randomly allocated to four groups (n = 6): negative control, positive control, gel base, and the selected avocado leaf extract gel. Oral ulcers were induced with 50% acetic acid and evaluated macroscopically; one blinded tissue sample from each group was assessed histopathologically. Phytochemical screening detected alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. The selected gel produced a higher macroscopic healing score than the negative control and gel-base groups on day 7, although the positive control showed the highest score. Histopathological observations supported improved epithelial regeneration in the selected-formula group. Kruskal–Wallis analysis showed a difference among groups (p < 0.001), and the prespecified comparison between the negative control and selected formula was significant (p = 0.004). These findings indicate that avocado leaf extract gel warrants further investigation as a topical candidate for oral-ulcer healing.
Co-Authors Gioamanda Dwi Sumarni Hidayat, Taufik Septiyan