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Nofrizal Nofrizal
Department of Clinical Pharmacy, Faculty of Health Science, Universitas Baiturrahmah, Padang, West Sumatra, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Evaluasi Aktivitas Penghambatan α-Amilase, α-Glukosidase, dan Aktivitas Antioksidan secara In Vitro dari Ekstrak Etanol Lima Sayuran Indonesia: Pendekatan Multivariat dan Korelasi Nofrizal Nofrizal; Fatma Haspa Anzalmi; Lusia Eka Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1806

Abstract

Postprandial hyperglycemia and its associated oxidative stress are recognized as pivotal pathological hallmarks driving the progression of type 2 diabetes mellitus and its vascular complications. This study aims to evaluate and comparatively analyze the in vitro α-amylase, α-glucosidase inhibitory activities, alongside the free radical scavenging capacities, of ethanolic extracts derived from five widely consumed fresh vegetables in Indonesia: Carica papaya, Momordica charantia, Gigantochloa atter, Diplazium esculentum, and Luffa acutangula. Bioactivity assays were conducted utilizing starch-iodine, p-nitrophenyl-α-D-glucopyranoside, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methodologies. The experimental findings demonstrated that D. esculentum extract exhibited the most pronounced dual-inhibitory efficacy against α-amylase (IC50 138.50 µg/mL) and α-glucosidase (IC50 38.20 µg/mL). Furthermore, D. esculentum and C. papaya extracts demonstrated strong antioxidant capacities among all evaluated samples. Principal Component Analysis (PCA) and Pearson correlation analyses confirmed a strong positive correlation between free radical scavenging capacity and carbohydrate-hydrolyzing enzyme inhibition. In conclusion, D. esculentum emerges as a premier functional vegetable candidate, exhibiting remarkable dual-action therapeutic properties for the attenuation of postprandial hyperglycemia and mitigation of oxidative stress.
Co-Authors Fatma Haspa Anzalmi Lusia Eka Putri