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Agus Susanto
Department of Periodontics, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia

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The correlation between interleukin-1β levels and aggressive periodontitis: A scoping review Agus Susanto; Yanti Rusyanti; Nu’ty Hasya Chinta Andari Effendi
Scientific Dental Journal VOLUME 7, ISSUE 2, MAY - AUG 2023
Publisher : Faculty of Dentistry, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/sdj.v7i2.18911

Abstract

Aggressive periodontitis is a multifactorial disease; the body’s immune response is one of the factors that contributed to the disease development. One of the responses is in the form of the secretion of cytokines—that is, interleukin1β (IL-1β). The secretion of the said cytokine influences the development of periodontitis,particularly the occurrence of rapid bone loss. This study aimed to confirm whether there is a correlation between the levels of IL-1β and the severity of aggressive periodontitis from collected sources. The research performed is a type of literature review that employs the scoping review method to map the results of the analysis from among the topics discussed. Article searches were performedon four databases—PubMed, Cochrane Library, Google Scholar, and Science Direct—using keywords with the Boolean Operators method. In addition, a manual search wasalso performed. The articles were selected with reference to the Preferred Reporting Items for Systematic Reviews and MetaAnalyses Extension for Scoping Review (PRISMA-ScR) flow in accordance with the predetermined inclusion and exclusion criteria. This led to the collection of 10 relevant articles, which were reviewed by reviewing the levels of IL-1β in an individual with aggressive periodontitis. In addition, how much bone damage occurs is seen through the depth of the pocket. Eight of ten articles showed a correlation between levels of IL-1β and bone loss in aggressive periodontitis. Elevated IL-1β levels in patients with aggressive periodontitis reveal a correlation with the severity of the disease that is bone loss.
The correlation between the frequency of food consumption containing gluten and casein toward caries in children with autism spectrum disorders Tiffany M Indrawati; Agus Susanto; Inne S Sasmita
Scientific Dental Journal VOLUME 7, ISSUE 2, MAY - AUG 2023
Publisher : Faculty of Dentistry, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/sdj.v7i2.18914

Abstract

Background: Foods containing gluten and casein are widely consumed by children with autism spectrum disorder (ASD). Indeed, they are among their favorite foods. These foods contain carbohydrates, the primary substrate causing caries. Dental caries is one of the oral manifestations in children with ASD due to an imbalance in the demineralization and remineralization of tooth enamel. This study aimed to determine the relationship between food containing gluten and casein and the incidence of dental caries in children with ASD at the Biruku Indonesia Foundation (Bandung City, Java, Indonesia). Methods: This quantitative study used an analytical observational design with a cross-sectional approach. The research sample consisted of 17 subjects selected using the total sampling technique. Data were obtained after the Food Frequency Questionnaire (FFQ) and intraoral examination (DMFT/dmft score) were completed by the children’s parents. Correlation analysis was performed using Spearman’s rank test. Results: A total of 11 children, 64.7% had a low frequency of consuming food containing gluten and casein, whereas 6 children (35.3%) had a high frequency with a high dmft index (6.2) and a low DMFT index (1.5). Correlation analysis showed a negative correlation or inverse relationship between the two variables. Moreover, a significant relationship was found between consuming food containing gluten and casein and the dmft score (P value = 0.0498) and DMFT score (P value = 0.0383). Conclusion: Consuming food containing gluten and casein has a negative correlation or inverse relationship with dental caries in ASD children.
Co-Authors Inne S Sasmita Nu’ty Hasya Chinta Andari Effendi Tiffany M Indrawati Yanti Rusyanti