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All Journal Indonesian Journal of Jamu
Fania Putri Luhurningtyas
Pharmacy Study Program, Department of Nutrition, Food Technology, and Pharmacy, Tidar University, Barito 2, Magelang City 56114, Central Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Leukocyte Responses to Karika (Vasconcellea pubescens) Leaf Ethanol Extract in Carrageenan-Induced Mice Fania Putri Luhurningtyas; Dwi Cahya Kumalasari
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.448

Abstract

Inflammation involves systemic changes in leukocyte counts. This study characterized the phytochemical constituents of ethanol extract of karika (Vasconcellea pubescens) leaves and evaluated leukocyte responses in carrageenan-induced mice. The extract was prepared by maceration with 70% ethanol and analyzed by qualitative phytochemical screening and thin-layer chromatography. Twenty-four male Swiss Webster mice were randomized to six groups: negative control, vehicle control, diclofenac, and extract at 100, 200, or 400 mg/kg. Leukocyte counts were measured at baseline and 3 and 6 h after carrageenan induction. Friedman tests showed significant within-group changes over time in all groups (p < 0.05). Mean leukocyte counts at 3 and 6 h were descriptively lower in extract-treated groups than in negative and vehicle controls, with the 400 mg/kg group approaching diclofenac values. Alkaloids, flavonoids, and tannins were detected. These findings are consistent with potential anti-inflammatory activity, although between-group efficacy was not statistically tested.
Co-Authors Dwi Cahya Kumalasari