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All Journal Journal of Food and Pharmaceutical Science Journal of Food and Pharmaceutical Sciences
Sri Gusriyani
Department of Pharmacy, Universitas Fort De Kock, Bukittinggi, Sumatera Barat, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Development of Natural Immunomodulatory Agents: Study of Bacang Leaf Activity against NK Cells with ELISA Reader (Study in vivo): An In Vivo Study Using ELISA Analysis Sri Gusriyani; Yulia Yesti; Wenti Wulandari; Harysa Oktaviani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27275

Abstract

The immune system is the body's ability to fight disease by eliminating various foreign substances that enter the body. One of its main components is the Natural Killer (NK) cell, which functions to destroy infected cells. This study aimed to evaluate the immunomodulatory activity of Bacang (Mangifera foetida L.) leaf fractions on NK cells in vivo using an enzyme-linked immunosorbent assay (ELISA). The study employed a pretest–posttest experimental design with a control group. A total of 18 mice were divided into six groups. NK cell parameters were analyzed from blood serum collected through the retro-orbital plexus before and after treatment. The results showed the greatest increase in the ethyl acetate fraction, from approximately 13.3 ng/mL before treatment to 21.3 ng/mL after treatment. These findings suggest that Bacang leaf fractions may enhance NK cell-associated immune responses in mice, with the highest immunomodulatory effect observed in the ethyl acetate fraction.
Development of Natural Immunomodulatory Agents: Study of Bacang Leaf Activity against NK Cells with ELISA Reader (Study in vivo): An In Vivo Study Using ELISA Analysis Sri Gusriyani; Yulia Yesti; Wenti Wulandari; Harysa Oktaviani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27275

Abstract

The immune system is the body's ability to fight disease by eliminating various foreign substances that enter the body. One of its main components is the Natural Killer (NK) cell, which functions to destroy infected cells. This study aimed to evaluate the immunomodulatory activity of Bacang (Mangifera foetida L.) leaf fractions on NK cells in vivo using an enzyme-linked immunosorbent assay (ELISA). The study employed a pretest–posttest experimental design with a control group. A total of 18 mice were divided into six groups. NK cell parameters were analyzed from blood serum collected through the retro-orbital plexus before and after treatment. The results showed the greatest increase in the ethyl acetate fraction, from approximately 13.3 ng/mL before treatment to 21.3 ng/mL after treatment. These findings suggest that Bacang leaf fractions may enhance NK cell-associated immune responses in mice, with the highest immunomodulatory effect observed in the ethyl acetate fraction.
Co-Authors Harysa Oktaviani Wenti Wulandari Yulia Yesti