<![CDATA[The Central Sterile Supply Department (CSSD) is a crucial unit for infection control within hospitals. To effectively conduct its operations, the CSSD at RS PKU Muhammadiyah Yogyakarta requires adequate human resources, facilities and infrastructure, and Standard Operating Procedures (SOPs)—all of which must be managed collaboratively to achieve service quality goals. This study aims to examine the human resources, availability of facilities and infrastructure, and SOPs within the CSSD unit at RS PKU Muhammadiyah Yogyakarta. A qualitative method employing a case study approach was used. Data were collected through in-depth interviews with three informants and through direct observation; informants were selected using purposive sampling and included the unit supervisor and two CSSD staff members. Methodological triangulation was employed to ensure data validity. The results indicate that staffing levels and training received align with the 2009 Ministry of Health guidelines on CSSD management, although work structure requirements have not yet been fully met. While the availability of Personal Protective Equipment (PPE) complies with Ministry of Health guidelines, the workspace and existing facilities/infrastructure are not yet optimal or fully compliant with Minister of Health Regulation Number 40 of 2022 regarding technical requirements for hospital buildings, infrastructure, and medical equipment. The hospital has established policies in the form of SOPs to guide CSSD operations. Keywords : CSSD, Facilities, Human resources, SOP, Sterile department]]>
