This study was conducted to analyze and determine the influence of leadership and motivation on teacher professionalism at Public Secondary Education 20 of September Metinaro. The background of this research stems from the phenomenon of low teacher professionalism observed in the learning process, such as teachers arriving late to class, low enthusiasm in teaching, monotonous teaching methods, and ineffective communication between teachers and students. To improve teacher professionalism, school leadership and work motivation are considered important factors that need further investigation. This research employed a quantitative approach with a survey method. The population consisted of all teachers at Public Secondary Education 20 of September Metinaro, while the sample was determined proportionally. The data collection instrument used was a questionnaire that had been tested for validity and reliability. The independent variables in this study were leadership (X1) and motivation (X2), while the dependent variable was teacher professionalism (Y). The data were analyzed using descriptive and inferential statistical techniques, including multiple linear regression tests to examine the partial and simultaneous effects of the independent variables on the dependent variable. The findings revealed that leadership has a significant effect on teacher professionalism, motivation also has a positive and significant effect, and both leadership and motivation simultaneously have a significant effect on teacher professionalism at Public Secondary Education 20 of September Metinaro. Therefore, it can be concluded that the improvement of teacher professionalism requires the support of effective school leadership as well as strong teacher work motivation. The results of this study are expected to serve as a reference for schools, education policymakers, and future researchers in formulating strategies to enhance teacher quality and the overall quality of education.