This study evaluates whether Indonesia’s risk-based licensing regime for chicken farming adequately incorporates biological risk control within the framework of Maqasid Sharia. It compares the licensing instruments and procedures under Law Number 6 of 2023 concerning Job Creation and Government Regulation Number 28 of 2025 concerning the Implementation of Risk-Based Business Licensing with Uzbekistan’s veterinary-based licensing system to assess preventive verification and biosecurity safeguards. Using a socio-legal method with statutory and comparative approaches, this research examines the Indonesian and Uzbek legal frameworks for poultry business licensing. The findings reveal three main issues. First, Indonesia’s OSS-RBA primarily emphasizes administrative risk classification and investment facilitation, while measurable biological risk indicators remain absent from licensing decisions. risk-based licensing model prioritizes administrative risk classification and investment facilitation, while substantive biological risk indicators are not explicitly integrated into pre-licensing verification. Second, the lack of standardized biological criteria contributes to fragmented environmental and biosecurity assessment, resulting in legal uncertainty. Third, Uzbekistan integrates veterinary verification and traceability, and biosecurity standards into its licensing framework, demonstrating a stronger preventive approach. Accordingly, this study proposes the Bio-Prophetic Matrix as a socio-legal framework that operationalizes Hazard, Exposure, Vulnerability, Scale, Biosecurity, and Proximity (H-E-V-S-B-P) within the principles of Maqasid Sharia to strengthen biological risk assessment while preserving regulatory efficiency, legal certainty, and the preventive function of administrative licensing.