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Fuji Lestari
Program Studi Gizi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Mataram, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Analisis Efektivitas Terapi Kombinasi Metformin dan SGLT2 Inhibitor terhadap Kontrol Glikemik pada Pasien Diabetes Melitus Tipe 2 Fuji Lestari; Muhammad Ridwan
Journal of Applied Health Sciences Vol. 2 No. 3 (2026): Journal of Applied Health Sciences, August 2026
Publisher : Lembaga Penelitian dan Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70716/jahs.v2i3.290

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia caused by insulin resistance and impaired insulin secretion. This study aimed to analyze the effectiveness of combination therapy with metformin and Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors on glycemic control compared with metformin monotherapy. An analytical observational cross-sectional design with a retrospective approach was applied to 120 T2DM patients treated at the Endocrinology Clinic of Mataram General Hospital from January to December 2024. Medical record data included HbA1c, fasting plasma glucose, body mass index (BMI), and lipid profile. Data were analyzed using an independent t-test and multivariate linear regression. The results showed a mean HbA1c reduction of 1.42 ± 0.38% in the combination group, greater than the 0.87 ± 0.31% reduction in the monotherapy group (p < 0.05). The combination group also showed reductions in fasting plasma glucose and body weight without an increased risk of hypoglycemia. Multivariate analysis identified combination therapy as an independent predictor of improved glycemic control (β = 0.62; p = 0.001). Thus, metformin and SGLT2 inhibitor combination therapy was more effective than metformin monotherapy in improving glycemic control in patients with T2DM.
Co-Authors Muhammad Ridwan