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Lingga Pradipta
Department of Pediatrics, faculty of medicine, Hasanuddin University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Association Between Serum Vitamin D and Hepcidin Serum Levels in Children with Chronic Kidney Disease: A Cross-Sectional Study Jusli Aras; Lingga Pradipta; Syarifuddin Rauf
Journal of Biomedicine and Translational Research Vol 12, No 2 (2026): August 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i2.30284

Abstract

Background: Chronic kidney disease (CKD) is a major health issue in children and is frequently complicated by anemia, which is associated with poor outcomes. Hepcidin, a central regulator of iron metabolism, is elevated in CKD and exacerbates anemia. Emerging evidence suggests that vitamin D may influence anemia through effects on inflammation and erythropoiesis. However, the relationship between hepcidin and vitamin D in pediatric CKD remains unclear.Objective: This study aimed to evaluate the correlation between serum hepcidin and vitamin D levels in children with CKD.Methods: This cross-sectional study included 40 children aged 3 months to <18 years with CKD, recruited through consecutive sampling. Serum hepcidin and vitamin D levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Correlation analysis was performed to assess the relationship between hepcidin and vitamin D.Results: Mean serum hepcidin levels differed significantly according to vitamin D status (p < 0.001). A strong negative correlation was found between serum hepcidin and vitamin D levels (r = –0.856, p < 0.001), indicating that higher hepcidin concentrations were associated with lower vitamin D levels.Conclusion: Serum hepcidin levels are inversely correlated with vitamin D concentrations in children with CKD. These findings suggest that vitamin D deficiency may contribute to increased hepcidin production, potentially worsening anemia.
Co-Authors Jusli Aras Syarifuddin Rauf