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All Journal Jurnal Praba: Jurnal Rumpun Kesehatan Umum
Rifly Al Bukhori Sinaga
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Pirfenidon Dalam Penyembuhan Luka Bakar: Mekanisme, Efek Terapeutik, Dan Perspektif Masa Depan Sebuah Tinjauan Pustaka Ignatius Daniel Harijanto; Rifly Al Bukhori Sinaga; Muhammad Lazuardi Salman Asrofi; Syafiq Nabil Afthal; Muhammad Farelio Aldi
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 4 No. 2 (2026): Juni : Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v4i2.934

Abstract

Burns are a major global health problem and a cause of long-term morbidity, particularly through hypertrophic scarring and contractures, in which prolonged inflammation drives dysregulated healing and excessive fibrosis. Pirfenidone is an antifibrotic agent with anti-inflammatory, antiangiogenic, and antioxidant properties that may modulate wound healing. This review examined the mechanisms of action, therapeutic effects, and future potential of pirfenidone in burn wound healing. A literature search of PubMed and Google Scholar used the keywords "pirfenidone," "burn wound," "wound repair," and "scarring"; eight full-text primary studies - clinical trials and in vivo and in vitro experiments evaluating the effect of pirfenidone on wound healing, inflammation, angiogenesis, or fibrosis-were analyzed descriptively. Pirfenidone reduced pro-inflammatory mediators (IL-1β, IL-2, IL-6, IL-13, G-CSF, and MIP-1α), suppressed VEGF signaling, and modulated TGF-β and collagen deposition, reflecting anti-inflammatory, antiangiogenic, and antifibrotic activity. In a proof-of-concept trial in second-degree burn patients, it significantly improved re-epithelialization on day 7 (p = 0.029). Pirfenidone therefore shows promise as an adjuvant therapy for burn wound healing, although clinical evidence remains limited and larger studies are needed to confirm its efficacy and safety.
Co-Authors Ignatius Daniel Harijanto Muhammad Farelio Aldi Muhammad Lazuardi Salman Asrofi Syafiq Nabil Afthal