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Sumiwi Sri Adi
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Chemistry Medicine & Pharmacology Public Health

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EFFECTS OF THE ETHANOL EXTRACT OF Coleus scutellarioides ON BODY WEIGHT GAIN, ABDOMINAL CIRCUMFERENCE, AND LIVER INDEX IN HIGH-FAT DIET-FED MICE Ligarsari Dwi Lista; Halimah Eli; Sumiwi Sri Adi; Levita Jutti
Pharmacoscript Vol. 9 No. 2 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i2.2834

Abstract

Insulin resistance (IR) is characterized by a reduced responsiveness of insulin-sensitive tissues to endogenous insulin. Excessive caloric intake promotes the accumulation of free fatty acids in skeletal muscle and the liver, resulting in the formation of lipotoxic metabolites that impair insulin signaling and glucose uptake. Although Coleus scutellarioides has demonstrated antihyperglycemic activity, its potential to ameliorate obesity-associated metabolic disturbances, particularly high-fat diet-induced insulin resistance, remains largely unexplored. IR is also associated with visceral fat accumulation, which is strongly correlated with increased body weight. Flavonoids such as quercetin have been reported to ameliorate IR in high-fat diet-fed mice. This study aimed to evaluate the effects of ethanolic extract of C. scutellarioides on body weight gain, abdominal circumference, and liver index in high-fat diet-induced mice. Twenty-five male Swiss Webster mice were randomly divided into five groups (n = 5/group), including normal control, negative control, metformin-treated, EECS 250 mg/kg, and EECS 500 mg/kg. Data were analyzed using one-way ANOVA followed by the LSD post hoc test. EECS at doses of 250 mg/kg and 500 mg/kg significantly attenuated body weight gain by 15.06% and 13.34%, respectively, while also reducing abdominal circumference and liver index compared with the negative control group (p < 0.05). These findings suggest that EECS possesses anti-obesity activity and may ameliorate metabolic alterations associated with high-fat diet feeding.
THE ETHANOL EXTRACT OF Piper sarmentosum Roxb. IMPROVES METABOLIC PARAMETERS IN HIGH-FAT DIET-INDUCED MICE Khoiroh Itsna Rofiidatul; Levita Jutti; Sumiwi Sri Adi
Pharmacoscript Vol. 9 No. 2 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i2.2851

Abstract

A high-fat diet (HFD) is a major risk factor for insulin resistance (IR), obesity, and metabolic disorders. Flavonoids have been reported to attenuate IR and obesity-related metabolic alterations in experimental animal models. As Piper sarmentosum Roxb. leaves are rich in flavonoids and phenolic compounds, this study aimed to evaluate the effects of the ethanol extract of P. sarmentosum leaves (EEPS) on body weight, abdominal circumference, and liver index in HFD-fed mice. Mice were fed an HFD to induce IR and treated with EEPS at different doses. EEPS at 250 mg/kg significantly attenuated HFD-induced increases in body weight gain (12.80%), abdominal circumference (8.44%), and liver index (6.87%) compared with the negative control group (p < 0.05). These findings suggest that EEPS attenuates HFD-induced increases in body weight, abdominal adiposity, and liver index in mice.
Co-Authors Halimah Eli Khoiroh Itsna Rofiidatul Levita Jutti Ligarsari Dwi Lista