<![CDATA[Background: Adherence to antiretroviral (ARV) therapy is essential for maintaining viral suppression, preventing disease progression, and supporting the health of people living with HIV (PLHIV). However, quality of life is a multidimensional outcome that may be influenced not only by medication adherence but also by clinical, psychological, social, and environmental conditions. This study aimed to analyze the association between ARV medication adherence and quality of life among PLHIV receiving treatment at Lebdosari Primary Health Center, Semarang. Methods: This observational analytic study employed a cross-sectional design and was conducted at Lebdosari Primary Health Center from September to November 2025. A total of 65 PLHIV receiving ARV therapy were included using total sampling. Medication adherence was assessed using the Indonesian version of the MMAS-8, whereas quality of life was assessed using the Indonesian WHOQOL-HIV BREF. Data were analyzed descriptively and the association between medication adherence and quality of life was assessed using the Chi-square test, with statistical significance set at . Results: Most respondents had a moderate level of ARV medication adherence (49.2%), followed by high adherence (27.7%) and low adherence (23.1%). Regarding quality of life, 55.4% of respondents were categorized as having moderate quality of life and 44.6% as having high quality of life. The Chi-square analysis showed no statistically significant association between ARV medication adherence and quality of life ( ). Conclusion: No statistically significant association was observed between ARV medication adherence and quality of life among PLHIV at Lebdosari Primary Health Center. Further studies should consider clinical, psychological, social, and economic factors that may contribute to quality of life and should apply multivariable analysis to account for potential confounding factors.]]>
