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All Journal Medical and Health Journal
Muhammad Wirawan Harahap
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Indonesian Muslim University, Makassar, Indonesia
Medicine & Pharmacology

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Neutrophil-to-Lymphocyte Ratio and Acute Kidney Injury in Patients with Sepsis Admitted to Intensive Care Unit Andi Ghina Alya Zurayah; Muhammad Wirawan Harahap; Nurhikmawati Nurhikmawati; Faisal Sommeng; Tirta Swarga
Medical and Health Journal Vol 6 No 1 (2026): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.6.1.21442

Abstract

Acute Kidney Injury (AKI) is a common complication in patients with sepsis and contributes to high morbidity and mortality. Early detection of AKI remains challenging because conventional biomarkers have several limitations. The Neutrophil-to-Lymphocyte Ratio (NLR) is an easily obtainable inflammatory marker with potential value in identifying patients at risk of AKI; however, previous studies have reported inconsistent findings. This study aimed to analyze the association between the neutrophil-to-lymphocyte ratio (NLR) and the incidence of acute kidney injury (AKI) in septic patients admitted to the intensive care unit (ICU). This observational analytical study employed a retrospective design using medical record data from 75 septic patients. The mean NLR was significantly higher in patients with AKI than in those without AKI (27.57 vs. 13.66; p < 0.001). Receiver operating characteristic (ROC) analysis identified an optimal NLR cut-off value of 14.45 for predicting AKI, with a sensitivity of 72.7%, a specificity of 81.0%, and an area under the curve (AUC) of 0.788. These findings indicate that a higher NLR is significantly associated with the incidence of AKI among septic patients in the ICU. Therefore, NLR may serve as a useful inflammatory marker to support the early identification of AKI in patients with sepsis.
Co-Authors Andi Ghina Alya Zurayah Faisal Sommeng Nurhikmawati Nurhikmawati Tirta Swarga