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All Journal Jurnal Riset Multidisiplin Edukasi
Eni Widayati
Bagian Kimia Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang
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PENGARUH PEMBERIAN EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea) TERHADAP KADAR IL-10 (INTERLEUKIN 10) (Studi Ekperimental pada Tikus putih strain Wistar jantan yang dipapar Asap Rokok) Nidya Zaim Ufairoh; Eni Widayati
Jurnal Riset Multidisiplin Edukasi Vol. 3 No. 8 (2026): Jurnal Riset Multidisiplin Edukasi (Agustus 2026)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v3i8.2532

Abstract

Cigarette smoke exposure contains toxic substances such as nicotine and various harmful compounds that can induce oxidative stress and disrupt immune regulation. This condition stimulates inflammatory and anti-inflammatory responses, including changes in Interleukin-10 (IL-10) levels. Butterfly pea flower (Clitoria ternatea L.) contains flavonoids and anthocyanins with antioxidant and anti-inflammatory properties that may modulate inflammatory responses caused by cigarette smoke exposure. This study aimed to determine the effect of ethanol extract of butterfly pea flower on IL-10 levels in male Wistar rats exposed to cigarette smoke. This was an experimental study using a post-test only control group design involving 30 male Wistar rats divided into five groups. Treatments were administered for 14 days. On day 15, blood samples were collected and IL-10 levels were measured using ELISA. Data were analyzed using One-Way ANOVA followed by Post-Hoc LSD test. The mean IL-10 levels were 0.350 ng/mL (normal control), 0.818 ng/mL (negative control), 0.566 ng/mL (aspirin), 0.806 ng/mL (200 mg/200gBW), and 0.961 ng/mL (400 mg/200gBW). One-Way ANOVA showed significant differences among groups (p < 0.05). The results showed significant differences among groups (p < 0.05). It can be concluded that ethanol extract of Clitoria ternatea affects IL-10 levels in male Wistar rats exposed to cigarette smoke.
Co-Authors Nidya Zaim Ufairoh