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All Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Aty Frisianty
Department of Pediatrics, Muhammadiyah University of Surabaya, Surabaya, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Bronchopneumonia and Multiorgan Dysfunction in a 10-month-old Infant with Down Syndrome Dwi Wulandari; Yusian Eri Fitria; Aty Frisianty
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 13, No 1 (2026): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.13.1.2026.50-56

Abstract

Background: Common chromosomal disorders like Down Syndrome (DS) are linked to a high rate of congenital abnormalities, especially hypothyroidism and congenital heart disease (CHD).Presentation Case: This case report presents a 10-month-old female with DS who was brought to the emergency department with respiratory distress, poor weight gain, and delayed development. Physical examination revealed characteristic dysmorphic features, hypotonia, and a systolic murmur. Investigations showed elevated TSH and FT4, consistent with congenital hypothyroidism, while echocardiography confirmed the presence of ASD.Discussion: This case illustrates the multisystem involvement commonly observed in Down syndrome, including congenital hypothyroidism and atrial septal defect, both of which are major contributors to morbidity and mortality. The co-occurrence of recurrent respiratory infections, heart disease, and endocrine dysfunction underscores the need for early screening, multidisciplinary management, and comprehensive care to improve outcomes in children with Down syndrome.Conclusion: Early detection of CHD and hypothyroidism in children with Down syndrome is essential to prevent complications and support optimal growth and development through timely, multidisciplinary intervention.
Co-Authors Dwi Wulandari Yusian Eri Fitria