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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Suyata -
Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya/Mohammad Hoesin General Hospital, Palembang
Medicine & Pharmacology

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The Role of Lipopolysaccharide-Binding Protein in Hepatitis B-Related Cirrhosis: Is There a Link to Portal Hypertension? Ety Febrianti; Suyata -; Legiran -; Imam Suprianto; Vidi Orba Busro; Muhamad Ayus Astoni; Anjab Akmal Sya'roni
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 2 (2026): VOLUME 27, NUMBER 2, August, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2722026111-118

Abstract

Background: Bacterial translocation plays a critical role in the pathogenesis of systemic inflammation in cirrhosis, particularly in cases related to chronic Hepatitis B infection. Lipopolysaccharide-binding protein (LBP) is a key acute-phase reactant that reflects exposure to endotoxins, yet its relationship with portal hypertension remains poorly defined. This study aimed to evaluate the correlation between serum LBP levels and spleen stiffness, a non-invasive marker of portal hypertension in patients with Hepatitis B-related cirrhosis. Methods: A cross-sectional study was conducted on 50 patients with Hepatitis B-related cirrhosis at Dr. Mohammad Hoesin Hospital, Palembang, between September and December 2024. Serum LBP levels were measured, and spleen stiffness was assessed using transient elastography. Laboratory parameters, clinical characteristics, and virologic profiles were analyzed. Correlation analyses were performed using Pearson’s or Spearman’s correlation tests, as appropriate.Results: The mean serum LBP level was 20.49 ± 7.34 μg/mL, while the mean spleen stiffness was 71.69 ± 17.74 kPa. A negative but non-significant correlation was observed between serum LBP levels and spleen stiffness (r = -0.263, p = 0.065). Serum LBP levels showed significant negative correlations with total, direct, and indirect bilirubin levels, as well as transaminase levels (AST and ALT), but not with platelet count, HBV DNA levels, or coagulation parameters.Conclusion: In patients with Hepatitis B-related cirrhosis, serum LBP may reflect systemic inflammatory activity rather than the severity of portal hypertension. Further studies are needed to determine its prognostic value in cirrhotic complications.
Co-Authors Anjab Akmal Sya'roni Ety Febrianti Imam Suprianto Legiran - Muhamad Ayus Astoni Vidi Orba Busro