<![CDATA[Dewandaru (Eugenia uniflora) has long been used in traditional medicine due to its antimicrobial and antihypertensive properties. Beyond its phytochemical constituents, this plant hosts endophytic microbes, especially fungi from the genera Aspergillus and Pestalotiopsis, which are capable of producing bioactive secondary metabolites.This review explores the diversity of endophytic microbes in Dewandaru and their bioactive compounds to grasp their potential application in biotechnology and medical field. Studies have shown that isolates from Dewandaru stems exhibit antibacterial activity against Staphylococcus aureus and Escherichia coli. The metabolites produced include alkaloids, flavonoids, xanthones, and spiroketals, demonstrating pharmacological effects such as antimicrobial, anticancer, anti-inflammatory, antioxidant, and antidiabetic activities. Moreover, compounds like chloropupukeananin and pestalotheol have shown inhibitory effects on HIV replication. In biotechnology, these endophytes hold promise for sustainable metabolite production through fermentation and biosynthesis. Endophytic microbes from Dewandaru possess great potential as sources of natural therapeutic agents. The biosynthetic diversity of Aspergillus and Pestalotiopsis supports the development of nature-based medicines. However, further research is needed to ensure consistent production, clarify mechanisms of action, and evaluate biosafety for broader medical applications.]]>
