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All Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Muh Husni Cangara
Department of Anatomical Pathology, Faculty of Medicine Hasanuddin University, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Eosinophilic Myocarditis: A Rare Histopathological Finding and Diagnostic Challenge in Sudden Cardiac Death Aries Maulana; Jasa Nita Listiana; Denny Mathius; Muh Husni Cangara; Natalia Widjaya
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 12 No. 3 (2026)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/7hc5e947

Abstract

Background: Eosinophilic myocarditis (EM) is a rare inflammatory myocardial disorder that may cause arrhythmia, heart failure, cardiogenic shock, or sudden cardiac death. Objectives: To describe the forensic and histopathological findings of a fatal case of EM and emphasize appropriate interpretation of pathological diagnosis, mechanism of death, and underlying etiology. Methods: A forensic autopsy and histopathological examination were performed in a 48-year-old man who died suddenly without documented preceding cardiac symptoms. Results: Autopsy revealed cardiomegaly, myocardial discoloration and necrosis, intracavitary mural thrombi, and no significant macroscopic coronary stenosis. Histopathology demonstrated myocyte degeneration and necrosis with dense eosinophil-rich inflammatory infiltration accompanied by lymphocytes, neutrophils, histiocytes, and hemorrhagic foci. These findings strongly supported EM as the principal pathological diagnosis. However, the etiology remained undetermined because complete toxicological, hematological, parasitological, autoimmune, and immunohistochemical investigations were not documented. A fatal arrhythmia was considered a plausible mechanism of sudden death but was not directly demonstrated. Conclusions: This case highlights the importance of integrating autopsy and histopathological findings while distinguishing pathological diagnosis, probable mechanism of death, and etiological classification in sudden death associated with EM.
Maternal Malperfusion and Placental Necrosis in Sudden Maternal Death: A Forensic and Histopathological Case Analysis of Severe Preeclampsia Jasa Nita Listiana; Annisa Anwar Muthaher; Afriani Early; Muh Husni Cangara; Ressy Dwiyanti; Andini Febrianty; Zulfikar Gaffar Assegaf; Aries Maulana
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 12 No. 3 (2026)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/5j9b3a33

Abstract

Background: Sudden maternal death associated with hypertensive disorders of pregnancy can be difficult to interpret when clinical and autopsy documentation is incomplete. Objectives: To describe a sudden maternal death in a woman with clinical and placental findings suggestive of severe preeclampsia and to emphasize the diagnostic value and limitations of placental histopathology. Methods: A forensic case of a 29-year-old gravida 3 para 2 woman at 32 weeks of gestation who was found dead at home was reviewed using available clinical records, laboratory findings, toxicology, placental gross examination, and histopathology. Results: Two weeks before death, headache, blurred vision, epigastric pain, hypertension, and proteinuria were documented. Laboratory findings included proteinuria +3, hematuria +1, and serum creatinine 2.1 mg/dL. Toxicological screening was negative. The placenta showed pale, firm infarcted areas. Histopathology demonstrated focal villous necrosis, ghost villi, and fibrinoid necrosis of maternal spiral arteries, consistent with maternal vascular malperfusion. Complete maternal organ findings and full exclusion of other major causes of sudden maternal death were unavailable. Conclusions: The findings strongly support severe preeclampsia as the underlying maternal condition associated with death; however, the immediate mechanism of death remains undetermined. Placental histopathology is valuable when integrated with complete clinical and forensic evaluation.
Co-Authors Afriani Early Andini Febrianty Annisa Anwar Muthaher Aries Maulana Aries Maulana Denny Mathius Jasa Nita Listiana Jasa Nita Listiana Natalia Widjaya Ressy Dwiyanti Zulfikar Gaffar Assegaf