Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan
Taufiq Siregar, Mara Imam
Unknown Affiliation
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Mekanisme Resistensi Isoniazid &Mutasi Gen KatG Ser315Thr (G944C) Mycobacterium tuberculosis Sebagai Penyebab TerseringResistensi Isoniazid Taufiq Siregar, Mara Imam
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 3 No. 2 (2015): JAMBI MEDICAL JOURNAL Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (889.211 KB) | DOI: 10.22437/jmj.v3i2.3088

Abstract

ABSTRACT Resistance to anti-tuberculosis drugs mainly occurs due to a mutation in the genes of Mycobacterium tuberculosis. Mutations can be induced by inadequate therapeutic levels of drug, mainly due to non-compliance for taking the drug. Therefore, the use of anti-tuberculosis drugs inappropriately and irregularly can lead to mutation in the gene encoding the target of anti-tuberculosis drugs. Inadequate therapeutic levels of drug due to non-compliance of patients taking isoniazid was the most frequent causing mutations in  KatG (Ser315Thr) gene. Therefore, concluded that this mutation was the commonest cause of INH resistance and could be a potential genetic marker for predicting MDR-TB. 
Co-Authors