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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Folia Medica Indonesiana
Nurhidayat, Ade Apon
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Immunology & microbiology Neuroscience Other

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The role of cyclin D1 and vascular endothelial growth factor (VEGF) in radiotherapy response of undifferentiated nasopharyngeal carcinoma Nurhidayat, Ade Apon; Afiati, .; Usman, Hermin Aminah; Hernowo, Bethy Suryawathy
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (844.579 KB) | DOI: 10.19106/JMedScie/005004201802

Abstract

Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate in SoutheastAsia included in Indonesia. Radioresistance is a major obstacle for a successful treatmentof NPC. DNA repair in the cell cycle and angiogenesis factors affect the response oftumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and vascularendothelial growth factor (VEGF) as an angiogenesis factor are considered to play arole in the occurrence of radioresistance. The objective of this study was to evaluatethe association between cyclin D1 and VEGF expressions with radiotherapy responsein undifferentiated NPC. This study used a retrospective case control analysis design.Secondary data from medical records of patients diagnosed as undifferentiated NPC whoreceived a complete radiotherapy at the Department of Radiation Oncology, Dr. HasanSadikin General Hospital, Bandung. There were 44 samples divided into radiosensitive(22 samples) and radioresistant (22 samples) groups. Immunohistochemical examinationof cyclin D1 and VEGF expressions was performed on paraffin blocks of patients’nasopharyngeal biopsy. Data analysis used Chi-Square test with p ≤0.05. Cyclin D1 wasexpressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitivegroup (p<0.05), VEGF was strongly expressed in 77.3% of the radioresistant group and54.5% in the radiosensitive group (p>0.05). In conclusion, there is significant associationbetween cyclin D1 expression with radiotherapy response in undifferentiated NPC.However, there is no association between VEGF expression with radiotherapy response.
The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma Nurhidayat, Ade Apon; Afiati, Afiati; Usman, Hermin Aminah; Hernowo, Bethy Suryawathy
Folia Medica Indonesiana Vol. 56 No. 4 (2020): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1619.919 KB) | DOI: 10.20473/fmi.v56i4.24554

Abstract

Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nasopharyngeal carcinoma. This study used a retrospective case control analysis design, secondary data from medical records of patients diagnosed as undifferentiated nasopharyngeal carcinoma who received complete radiotherapy at the Radiation Oncology Department  Dr Hasan Sadikin Bandung were taken. There were 44 samples divided into radiosensitive (22 samples) and radioresistant (22 samples) groups. Immunohistochemical examination of Cyclin D1 and VEGF was performed on paraffin blocks of patients' biopsy. Data analysis using Chi-Square test (p ≤0.05) , OR 95% CI. Cyclin D1 expressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitive group (p<0.05) and the OR 4,385 (0.993-19.356), VEGF was strongly expressed in 77.3% of the radioresistant group and 54.5% in the radiosensitive group (p>0.05). As conclusion, there were significant association between Cyclin D1 with radiotherapy respons in undifferentiated nasopharyngeal carcinoma. The stronger immunoexpression of Cyclin D1, the higher likelihood of radioresistancy. VEGF immunoexpression showed no significant association with radiotherapy response.
Co-Authors . Afiati, . Afiati Afiati Bethy Suryawathy Hernowo Hermin Aminah Usman