<![CDATA[This review analyses the potential for synergistic integration between golden sea cucumber (Stichopus hermanni) collagen and snakehead fish (Channa striata) albumin via a mucoadhesive oral microneedle patch delivery system to accelerate wound healing. This study employs a comprehensive literature review, exploring the biology of mucosal wound healing, the biochemical profiles of the golden sea cucumber and snakehead fish components, and the mechanism of microneedle technology. Type I collagen from the golden sea cucumber acts as a structural scaffold and a provider of proliferative signals through its in-teraction with integrins. Meanwhile, catfish albumin functions as an anti-inflammatory agent, an osmotic pressure balancer, and a provider of essential me-tabolic nutrients (such as zinc and amino acids) that support the proliferation phase. The use of dissolving microneedle technology enables precise, pain-free penetration through the epithelial barrier, whilst delivering the effects of percutaneous collagen induction therapy via mechanical microtrauma that sti-mulates the healing cascade. The design of a double-layered hybrid patch with a mucoadhesive layer has been shown to maintain drug retention in the moist oral cavity environment. The integration of S.hermanni collagen and C.striata albumin into the oral microneedle system promises a revolutionary therapeutic approach to the management of mucosal wounds through the simultaneous modulation of the NF-?B and TGF-?1 signalling pathways.]]>
