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All Journal MDJ (Makassar Dental Journal)
Azzahrah Dhaifatul Azizah
Department of Dental Material Science and Technology, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Dentistry

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Marine-derived 9-octadecenoic acid and a-tocopherol acetate as antioxidant and anti-inflammatory agents in oral health: Asam 9-oktadekenoat yang berasal dari laut dan asetat a-tokoferol sebagai agen antioksidan dan antiinflamasi dalam kesehatan mulut Asmawati Amin; Alqarama Mahardhika Thalib; Bahruddin Thalib; Azzahrah Dhaifatul Azizah; Zakirah Taqiyyani Toripuji
Makassar Dental Journal Vol. 15 No. 2 (2026): Volume 15 Issue 2 August 2026
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v15i2.1158

Abstract

Natural bioactive compounds such as a-tocopherol and 9-octadecenoic acid (OOA), both found in Stichopus hermanii, have demonstrated potential antioxidant and anti-inflammatory properties. This article reviews systematically and compare the biological activities of a-tocopherol and OOA in managing oxidative and inflammatory processes relevant to the oral cavity. A descriptive-comparative literature review was conducted using PubMed, ScienceDirect, MDPI, and Google Scholar (2015-2025). Inclusion criteria covered in vitro, in vivo, clinical, and in silico studies evaluating the antioxidant and anti-inflammatory effects of a-tocopherol or OOA. a-tocopherol primarily acted by enhancing antioxidant defenses and suppressing inflammatory signaling, while OOA modulated proinflammatory pathways and epigenetic mechanisms. It is concluded that a-tocopherol and OOA exhibit complementary mechanisms in reducing oxidative stress and inflammation. Their combined use and marine-derived origin from S.hermanii offer promising directions for future research and therapeutic application in oral health.
Co-Authors Alqarama Mahardhika Thalib Asmawati Amin Bahruddin Thalib Zakirah Taqiyyani Toripuji