<![CDATA[Background: Tuberculosis (TB) remains a significant public health issue in Indonesia, despite the availability of effective anti-TB treatments. Sustained medication adherence is essential for treatment success and may contribute to improved Health-Related Quality of Life (HRQoL), which is also influenced by clinical and sociodemographic factors. However, evidence regarding the association between medication adherence and HRQoL among outpatients with drug-susceptible tuberculosis in Indonesia remains limited. Methods: A cross-sectional analytical study was performed on 133 outpatients with drug-susceptible tuberculosis at Rumah Sakit Pusat Angkatan Laut dr. Ramelan Surabaya. Medication adherence was assessed using the Comprehensive Medication Adherence Assessment Scale-12 (CMAAS-12), and HRQoL was assessed using the World Health Organization Quality of Life-BREF (WHOQOL-BREF). The Indonesian CMAAS-12 showed nine valid items (r=0.376–0.616; critical r=0.361) and a reliability coefficient of 0.50. Data were analyzed using chi-square tests and multivariable logistic regression in IBM SPSS Statistics 29.0, with a 95% confidence level and p<0.05 considered statistically significant. Results: Good medication adherence was observed in 58.6% of participants and was significantly associated with better HRQoL in the physical health (p<0.00), psychological (p<0.00), social relationships (p=0.04), and environmental (p<0.00) domains, but not overall QoL (p=0.08). Age, distance to hospital, and medication adherence were significant determinants of domain-specific HRQoL. Conclusion: Medication adherence is an important determinant of HRQoL in outpatients with drug-susceptible tuberculosis. Strengthening adherence-focused interventions may improve patient-centered outcomes and optimize tuberculosis management.]]>
