Background: Temporomandibular disorder (TMD) is a common condition frequently reported in individuals aged 20–40 years (early adulthood). Approximately 33% of the population experiences at least one symptom of TMD, and about 3.6%–7% have TMD of sufficient severity to require treatment. This indicates a high prevalence of TMD in this age group in Indonesia. One approach to improving diagnostic accuracy is the use of the 5 Major TMD Symptoms (5Ts) questionnaire. However, the 5Ts questionnaire is not currently available in Indonesian, necessitating its translation and cultural adaptation. Distribution of the questionnaire can be facilitated through information and communication technology, which is referred to in healthcare as telemedicine. Purpose: To evaluate the validity and reliability of the digital Indonesian version of the 5Ts questionnaire. Methods: This descriptive analytical study employed a cross-sectional design. Validity was assessed using the corrected item–total correlation test, and reliability was assessed using Cronbach’s alpha. The questionnaire was administered to 330 students at Universitas Sumatera Utara selected through purposive sampling according to the inclusion and exclusion criteria. Results: Validity testing yielded calculated r-values ranging from 0.392 to 0.533, all of which exceeded the critical r-value of 0.107, indicating that all questionnaire items were valid. The reliability analysis produced a Cronbach’s alpha value of 0.711, exceeding the acceptable threshold of 0.70 and confirming the questionnaire’s reliability. Conclusion: The digital-based Indonesian version of the 5Ts questionnaire is a valid and reliable instrument.