Department of Manpower as one of the unit The work of the Medan City Regional Apparatus which carries out authority government in the field of employment in Medan City. Manpower Office is A the current service developing that is not missed from problems including No existence development career and motivation Work to employee who makes decline performance employee . Development career and motivation Work is factors that can increase and decrease performance employees , research This aim For know whether influence development career and motivation Work to influential significant to performance employees at the Medan City Manpower Office. The author also limits the research to This restricted only for a sample of civil servant employees . population study This is 58 respondents , method data analysis used is multiple linear regression , Partial Test (t), Simultaneous Test (F) and Coefficient Test Determination (R 2 ). From the results research known Development Career with mark significance 0.041 < 0.05 with results mark thitung (2.089) > ttabel (1.673), p This can concluded in a way partial Development Career influential positive and significant to performance employee . Motivation Work with mark significance 0.041 < 0.05 with results mark thitung (4.299) > ttabel (1.673), p This can concluded in a way partial Motivation Work influential positive and significant to performance employee . If seen from F test results where mark significant 0.000<0.05 with results mark F Count (19,333) > F table (3,165) pages This can concluded development Career and Work Motivation Together influential positive and significant to performance employees . Results of coefficient test determination in study This obtained R2 value of 0.413. This is show that performance employee influenced by Development career and work motivation by 41.3%, while the remaining 58.7% is influenced by other factors that are not including in study This .