First-degree students have many experiences with academic problems, namely stress. Stress is a response to the burden received. Increased stress for students causes a depressive condition that adversely affects them. Management that can be used is coloringthe mandala pattern which can affect the endorphin hormone so that the individual is in a state of relaxation. The purpose of this study was to determine the effect of therapeutic coloring on mandala patterns on academic stress levels in first-degree students.The research method in this study used a type of pre-experimental research with the PretestPosttest One Group approach. The number of samples in this study amounted to 60 firstlevel students nursing undergraduate study program at Bhakti Kencana Bandung Institute of health science with purposive sampling technique. The instruments used were the Student-life Stress Inventory questionnaire and the coloring book of the mandala pattern with measurements of stress levels carried out pre and post-test. Therapy for coloring the mandala pattern was carried out for 60 minutes with 3 meetings for 3 days in 1 weekusing pencil drawing media and mandala drawing patterns. Analysis of the data used is a paired t-test.The results showed that before the mandala pattern coloring therapy almost all (98.3%) students experienced moderate stress, after being given mandala pattern coloring therapy almost all (78.3%) students were still experiencing moderate stress but with a decrease in percentage and a small percentage (21.7%) students experienced a decrease in stress levels to mild stress. The paired t-test results showed a sig p-value of 0,000 < alfa (0.05). So it can be concluded that there is a therapeutic effect of coloring mandala patterns on academic stress levels at first-level students. Based on the results of this study, institutions are expected to be able to apply color therapy to the mandala pattern as a complementary therapy in handling students who experience academic stress.