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All Journal Journal of Diverse Medical Research: Medicosphere
Evrick Yonantiko
Unknown Affiliation
Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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Association between Poverty Rate and Stunting Prevalence in Central Java: A Narrative Review Qonita Abdillah Rosyida; Keyla Cantika Ismail; Evrick Yonantiko; Raihan Mahesa Ardiansyah
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 7 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i7.365

Abstract

Stunting refers to impaired growth and development in children resulting from chronic nutritional deficiencies, especially during the critical period of the first 1,000 days of life. This study aimed to generate more comprehensive empirical evidence on the association between poverty prevalence and stunting rates among districts and municipalities in Central Java. This study using a quantitative approach, this study analyzed secondary data through a correlational framework. The dataset covered all 36 administrative regions in Central Java Province, where district-level poverty rates and stunting prevalence served as the primary variables of analysis. The relationship between poverty and stunting identified should be interpreted as an association rather than a direct causal link. The findings suggest that poverty contributes to variations in child nutritional status, although it does not fully account for the complexity of underlying determinants. Therefore, poverty should be regarded as an important, yet not exclusive, factor. This study provides evidence of a significant positive association between district-level poverty rates and stunting prevalence in Central Java. The moderate correlation indicates that regions with higher poverty rates are more likely to have elevated stunting prevalence.
Biopigments from Monascus sp. as Potential Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α) Modulators: A Computational Approach: Original/Research Article Dyahati Wahyurini; Evrick Yonantiko; Immanuelle Kezia
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 7 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i7.372

Abstract

Monascus sp. produces biopigments (ankaflavin, monascin, and rubropunctatin) that have various biological activities, including a role in lipid metabolism through interaction with peroxisome proliferator-activated receptor alpha (PPAR-α). It plays an important role in regulating lipid metabolism and is a therapeutic target. Fenofibrate is one of the antihyperlipidemic drugs that targets PPAR-α. Therefore, this study aimed to evaluate the interaction of ankaflavin, monascin, and rubropunctatin with PPAR-α. The biopigments were analyzed using SwissADME and molecular docking with PPAR-α (PDB ID: 5HYK). The results showed that ankaflavin, monascin, and rubropunctatin complied with Lipinski’s Rule. Molecular docking revealed that all biopigments analyzed had good interactions with PPARα, with binding affinity values of ankaflavin -10.03 kcal/mol, monascin -10.38 kcal/mol, and rubropunctatin -10.62 kcal/mol. Rubropunctatin had the most negative binding affinity and the lowest predicted Ki (16.45 µM) among the tested biopigments and was most similar to the positive control, fenofibrate (−10.78 kcal/mol and 12.59 µM). In conclusion, these findings suggest that biopigments from Monascus sp. are potential candidates for PPAR-α modulators, particularly rubropunctatin. Further in vivo and in vitro investigations are necessary to validate these findings.
Co-Authors Dyahati Wahyurini Immanuelle Kezia Keyla Cantika Ismail Qonita Abdillah Rosyida Raihan Mahesa Ardiansyah