The rise in waste generation in Parepare City and the Ajatappareng region has created a need for a waste management system that reduces the environmental burden while generating energy. This study aims to formulate the concept of Industrial Symbiosis Architecture for the Waste-to-Energy Power Plant (PLTSa) in Parepare City by integrating waste processing, energy generation, education, and landscaping functions. The study employed a mixed-methods approach, using quantitative analysis to examine waste generation, processing capacity, and energy potential, as well as qualitative analysis of site characteristics and the application of architectural concepts. The analysis established a processing capacity of 300 metric tons per day and a potential electricity generation capacity of 6.08 MW. The Industrial Symbiosis Architecture concept is implemented through four forms of symbiosis: energy symbiosis through the utilization of electricity generated by WTE and its distribution to the PLN grid; material symbiosis through the use of combustion residues as supporting materials for the area; educational symbiosis through facilities such as a gallery, a mini-theatre, and observation trails; and landscape symbiosis through green open spaces, gardens, and buffer zones. Architecturally, the concept is realized through a radial mass layout, public, semi-public, and operational zoning, the separation of circulation paths, interconnections between building masses, and the integration of material and energy flows. This concept produces a framework for the PLTSa Industrial Area that integrates industrial, environmental, energy, educational, and community functions into a single area system.