Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Narra J
Jihan Ichsan
Department of Surgery and Biomedical Sciences, Faculty of Medicine, Universitas Khairun, Ternate, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Gut microbiome dysbiosis in traumatic brain injury: Implications for neurological recovery and microbiome-targeted interventions Jihan Ichsan; Aryandhito W. Nugroho
Narra J Vol. 6 No. 3 (2026): December 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i3.3141

Abstract

Traumatic brain injury (TBI) is a major cause of mortality and long-term neurological disability worldwide. In addition to primary brain damage, TBI induces complex secondary pathophysiological responses involving neuroinflammation, systemic immune dysregulation, gastrointestinal dysfunction, and alterations in the microbiota–gut–brain axis. Increasing attention has therefore been directed toward the role of gut microbiome dysbiosis in the progression of secondary brain injury and its potential as a therapeutic target. This narrative review aimed to synthesize current evidence regarding the relationship between TBI and disruption of the microbiota–gut–brain axis, with particular emphasis on the mechanisms underlying gut microbiome dysbiosis and its contribution to secondary brain injury. The review discusses neuroinflammatory responses, alterations in intestinal barrier integrity, enteric and autonomic nervous system involvement, vagal signaling, and microbiota-derived pathways implicated in brain–gut communication after TBI. In addition, the therapeutic rationale, available evidence, translational considerations, and current limitations of microbiome-targeted approaches, particularly probiotics and fecal microbiota transplantation, are critically discussed. This review provides an updated framework for understanding the microbiota–gut–brain axis in TBI and identifies areas requiring further mechanistic and clinical investigation.
Co-Authors Aryandhito W. Nugroho