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All Journal ODONTO Dental Journal
Fredy Mardiyantoro
(Scopus ID : 572083117580) 1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Brawijaya, Indonesia. 2. Department of Oral Biochemistry, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
Medicine & Pharmacology

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The Efficacy of Catfish Skin Gelatin (Pangasius djambal) on the Oral Cavity Soft Tissue Healing Fredy Mardiyantoro; Lukman Hakim Hidayat; Vira Dwiviasta Ade Ayu; Asma Syahidah Illia; Diva Alenta Arzeti
Odonto : Dental Journal Vol 13, No 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.106-118

Abstract

Background: Traumatic ulcers are common oral mucosal lesions causing discomfort, infection, and delayed healing. Conventional therapy is commonly used, but the use of herbal materials is expected to be an affordable and effective alternative therapy. Gelatin was chosen because it is a natural biomaterial rich in amino acids, which play a role in regulating inflammation and tissue regeneration, particularly in influencing the number of macrophages and lymphocytes in the inflammatory phase and fibroblast proliferation. The purpose of the study was to determine the effect of Pangasius djambal fish skin gelatin on the healing process of traumatic ulcers in Rattus norvegicus.Method: A Wistar rats (Rattus norvegicus) were used as research subjects. Traumatic ulcers were induced on the lower jaw labial mucosa using thermal trauma. Observations were made on days 3, 5, and 7. The number of macrophages, lymphocytes, and fibroblasts was counted using hematoxylin-eosin (HE) staining under a microscope at 400× magnification.Result: Based on the results of the One-way ANOVA parametric test, a value of (p < 0.05) was obtained, indicating a significant difference in the number of macrophages, lymphocytes, and fibroblasts between groups. Conclusion: Pangasius djambal skin gelatin can effect the healing process of traumatic ulcers in Rattus norvegicus.
Co-Authors Asma Syahidah Illia Diva Alenta Arzeti Lukman Hakim Hidayat Vira Dwiviasta Ade Ayu