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All Journal Biosaintifika: Journal of Biology & Biology Education
Haryanto Haryanto
Biotechnology Department, Faculty of Science and Technology, Universitas Muhammadiyah Bandung, Bandung, Indonesia
Agriculture, Biological Sciences & Forestry

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Protective Effects of Curculigo latifolia Root Extract on Testicular Function in Mice Exposed to 7,12-Dimethylbenz(A)Anthracene Haryanto Haryanto; Luthfia Hastiani Muharram; Agus Sutandi; Cusiyani Aprillia; Saepul Muhyi Amirullah; Faisal Anggi Pradita
Biosaintifika: Journal of Biology & Biology Education Vol. 18 No. 1 (2026): April 2026
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v18i1.38549

Abstract

The testis, a vital reproductive organ in males, is highly susceptible to damage from chemotherapy. The root of Curculigo latifolia contains secondary metabolites that have potential as anticancer agents and protective agents for reproductive health. This study aims to evaluate the protective potential of crude extract from C. latifolia in suppressing testicular carcinogenesis induced by DMBA in vivo. This study employed a completely randomized design with five treatment groups, including negative and positive controls, as well as three treatment groups receiving doses of C. latifolia root extract at 300, 600, and 900 mg/Kg body weight. Testicular carcinogenesis was induced by oral administration of DMBA at a dose of 20 mg/Kg body weight twice a week for six weeks. The data of sperm quality, including motility, viability, sperm concentration, and testicular microanatomical structures, analysed by ANOVA one-way test, revealed significant effects from oral administration of C. latifolia root extract (p < 0.05). Overall, C. latifolia root extract improves sperm quality and protects the testicular microanatomical structure against DMBA exposure. Novelty in this study explores the local herbal agent potential (C. latifolia root extract), decreasing reproductive damage and alopecia from DMBA carcinogenic effects. Thus, these findings directly contribute to reaching Sustainable Development Goal 3 (SDG3) by ensuring healthy lives and promoting well-being in all aspects for all ages.
Co-Authors Agus Sutandi Cusiyani Aprillia Faisal Anggi Pradita Luthfia Hastiani Muharram Saepul Muhyi Amirullah