<![CDATA[Breast cancer incidence is increasing annually, with the proportion of stage III cases reaching 47%. Neo-adjuvant chemotherapy is necessary for its treatment, but its success rate is relatively low. Tumor progression and chemotherapy resistance depend on the stage, internal variables, the type of chemotherapy used, and the patient's psychological state. This study aims to determine the effect of psychotherapy on the clinical response to chemotherapy in women with locally advanced breast cancer. This randomized controlled trial involved 48 subjects, randomly divided into two groups of 24 subjects each. The control group received neo-adjuvant chemotherapy. The treatment group received neo-adjuvant chemotherapy and psychotherapy intervention at Dr. Soetomo General Hospital, Surabaya. Each subject received an assessment by the surgical team, including tumor size measurement, and the psychiatric team, including a psychological profile after being diagnosed with breast cancer and requiring neo-adjuvant chemotherapy. The treatment group had 87.5% of subjects responding well to chemotherapy, with 3 (12.5%) having no response, with 75% having a partial response, 12.5% having a complete response, and 12.5% having stable disease. The control group had 66.7% of subjects not responding, and 33.3% having a good response to chemotherapy, with 75% having a stable disease and 33.3% having a partial response. Psychotherapy has an effect on the clinical response to chemotherapy in women with locally advanced breast cancer.]]>
