Prinsip utama yang sangat ditekankan dalam implementasi kurikulum merdeka adalah pendidikan yang berpihak pada murid. Salah satu langkah yang dapat dilakukan agar pembelajaran berpihak kepada murid adalah dengan menerapkan diferensiasi dalam pembelajaran. Tujuan penelitian ini adalah menganalisis keefektifan penerapan diferensiasi proses pada pembelajaran kimia kelas X di SMA Negeri 6 Kota Serang. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan menggunakan metode survei terhadap 127 responden. Pertanyaan diberikan untuk mengetahui pendapat murid tentang diferensiasi proses pada pembelajaran kimia di kelas X yang telah dilaksanakan selama semester pertama tahun ajaran 2022/2023. Berdasarkan hasil penelitian diketahui bahwa 63,0% responden menyatakan sangat puas atau puas; 34,6% menyatakan biasa saja; dan 2,4% menyatakan sangat tidak puas atau tidak puas terhadap diferensiasi proses melalui variasi metode pembelajaran. Selain itu, sebanyak 81,8% responden menyatakan sangat puas atau puas; 15,5% menyatakan biasa saja; dan 2,4% menyatakan sangat tidak puas atau tidak puas terhadap diferensiasi proses melalui variasi lokasi pembelajaran. The main principle that is highly emphasized in the implementation of the kurikulum merdeka is education that is pro-student. One of the steps that can be taken so that learning takes the side of students is to apply differentiation in learning. This study aims to analyze the effectiveness of implementing process differentiation in chemistry class X at SMA Negeri 6 Kota Serang. The type of research used is qualitative research using a survey method of 127 respondents. Questions were asked to find out students' opinions about process differentiation in chemistry learning in class X which was carried out during the first semester of the 2022/2023 academic year. Based on the research results, it is known that 63.0% of respondents stated that they were very satisfied or satisfied; 34.6% stated that it was normal; and 2.4% stated that they were very dissatisfied or dissatisfied with process differentiation through variations in learning methods. In addition, as many as 81.8% of respondents said they were very satisfied or satisfied; 15.5% said it was normal; and 2.4% stated that they were very dissatisfied or dissatisfied with process differentiation through variations in learning locations.