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Herwindra Hafis
Universitas Sari Mutiara Indonesia, Indonesia

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IgM antibody profile in patients with typhoid fever at a general hospital Herwindra Hafis; Dyna Grace Romatua Aruan; Denrison Purba; Cut Masyitah Thaib
Medical Laboratory Science Journal Vol. 1 No. 2 (2025): November 2025
Publisher : Kadewa Bakti Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67958/medlab.v1i2.64

Abstract

Typhoid fever remains a significant public health problem in endemic areas, so accurate and timely diagnosis is crucial in supporting clinical management. Serological testing for immunoglobulin M antibodies has been widely used to support early diagnosis, especially in health care facilities with limited laboratory resources. This study aimed to describe the immunoglobulin M antibody profile in patients with a clinical diagnosis of typhoid fever who underwent serological testing at a general hospital. This study used a descriptive observational design with a cross-sectional approach. Venous blood samples were taken from 20 patients suspected of having typhoid fever and analyzed using an immunochromatography test. Data analysis was performed descriptively. The results showed that most patients had positive immunoglobulin M test results. It indicates the presence of acute or ongoing infection. Meanwhile, the rest showed negative results, likely because testing was performed early in the infection before optimal antibody levels. These findings confirm the role of immunoglobulin M testing as a relevant diagnostic tool in detecting acute typhoid fever. Interpretation of serology results needs to consider the clinical context and timing of sample collection in order to make clinical decisions more accurate in healthcare practice.
Co-Authors Cut Masyitah Thaib Denrison Purba Dyna Grace Romatua Aruan