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All Journal Asian Journal of Fertility, Endocrinology, and Reproduction
I Wayan Arsana Wiyasa
Division of Fertility, Endocrinology, and Reproduction, Department of Obstetrics and Gynecology, Universitas Brawijaya/ Saiful Anwar General Hospital, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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Genistein Acts as an antiangiogenic and Inflammatory Modulator by Inhibits VEGFR2, TGF-β1, and COX-2 Levels in Peritoneal Endometriosis Lesion of Endometriosis Mice Sutrisno Sutrisno; Afiat Aji Wijaya; Effie Masyitha Siregar; Lilis Handayani; Hermawan Wibisono; Pande Made Dwijayasa; Nina Rini Suprobo; I Wayan Arsana Wiyasa
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 1 (2026): January 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i1.8

Abstract

Introduction: This research aims to determine whether genistein functions as an antiangiogenic and inflammatory modulator by decreasing levels of VEGFR2, TGF-β1, and COX-2 in the peritoneal fluid of mice with an endometriosis model. Methods: The study involved 32 healthy female Mus musculus mice, 20-30 g in weight and 2-3 months old, divided into eight groups: negative control group (healthy mice without treatment), an endometriosis model group (endometriosis-induced mice without genistein), and six treatment groups that received varying doses of genistein (0.13, 0.26, 0.52, 0.78, 1.04, and 1.3 mg/day, n=4). Measurement of VEGFR-2, TGF-β1, and COX-2 levels in endometriosis lesions in mouse models using an Enzyme Immunoassay (EIA), Mice enzyme-linked immunoassay (ELISA) Kit. Results: This study showed that the endometriosis model exhibited increased levels of VEGFR-2, TGF-β1, and COX-2. Administration of genistein significantly normalized these elevated levels. Genistein markedly reduced VEGFR-2, TGF-β1, and COX-2 levels in all the treatment groups. Conclusion: Genistein decreases levels of VEGFR-2, TGF-β1, and COX-2 in the peritoneal fluid of a mouse model of endometriosis by acting as an antiangiogenic and inflammatory modulator. Consequently, genistein holds potential as a therapeutic agent in the treatment of endometriosis.
Co-Authors Afiat Aji Wijaya Effie Masyitha Siregar Hermawan Wibisono Lilis Handayani Nina Rini Suprobo Pande Made Dwijayasa Sutrisno Sutrisno