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All Journal Asian Journal of Fertility, Endocrinology, and Reproduction
Sutrisno
Division of Fertility, Endocrinology, and Reproduction, Department of Obstetrics and Gynecology, Universitas Brawijaya/ Saiful Anwar General Hospital, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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5-O-methyl genistein of Phaleria macrocarpa Revealed a Potential Therapeutic Compound for Endometriosis Sutrisno; Maharani Maharani
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.39

Abstract

Introduction: Endometriosis is a gynecological disease characterized by pelvic pain and high inflammation in women. Phaleria macrocarpa fruit contains six flavonoids involved Eriodictyol, Glycitin, 5-O-methylgenistein, Catechin 7-O-beta-D-xyloside, 8-Prenylnaringenin, and Naringenin. In vivo experiment performed that flavonoid from Phaleria macrocarpa fruit potential as therapeutic agents for endometriosis. However, the mechanism of flavonoids from Phaleria macrocarpa was limited information. This study performed the endometriosis therapeutic mechanism of flavonoids from Phaleria macrocarpa through molecular docking. Methods In silico experiment was carried out of this study, canonical SMILES of six identified flavonoids from Phaleria macrocarpa were predicted the anti-inflammatory, antineoplastic, and antioxidant properties. Then, the highest biological properties was redocked with AKT, COX-2, AHR, and ESR by using Molegro Virtual Docker version 5.0. Result: According to the bioactivity prediction, six flavonoids of Phaleria macrocarpa performed antiinflammatory property ranged 0.599 – 0.751, low anti-inflammatory intestinal NSAID agent, and antineoplastic (uterine, cervical, and ovarian cancers). 5-O-methylgenistein showed highest breast cancer – resistant protein inhibitor. Molecular docking performed interaction of 5-O-methylgenistein and inhibited COX-2, AHR, ESR, and AKT. 5-O-methylgenistein induced apoptosis by caspase – 3 interactions. A proposed mechanism of 5-O-methylgenistein in endometriosis was reducing pain, inducing apoptosis, preventing cancer cell initiation, inhibiting proliferation and oncogenic cell. Conclusion: 5-O-Methylgenistein performed a promising plant constituent for endometriosis therapy.
Co-Authors Maharani Maharani