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Muh. Alfian Jafar
Department of Pediatrics, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Profile of Minimal and Non-Minimal Change Nephrotic Syndrome in Children: A Cross-Sectional Study Muh. Alfian Jafar; Syarifuddin Rauf; Dasril Daud
Green Medical Journal Vol 2 No 2 (2020): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v2i2.51

Abstract

Introduction: Idiopathic nephrotic syndrome (INS) is the most common kidney disease in children. Histopathological features classify the disease into minimal change nephrotic syndrome (MCNS) and non-minimal change nephrotic syndrome (NMCNS). Clinical and laboratory characteristics are considered to be useful in estimating the underlying pathological changes. This study aimed to assess the spectrum of clinical and laboratory profiles in children suffering from MCNS and NMCNS. Methods: This was a cross-sectional study using medical records of patients hospitalized at Dr. Wahidin Sudirohusodo Central General Hospital and Hasanuddin University Teaching Hospital from January 2016 to August 2018. Subjects were classified into MCNS and NMCNS groups and evaluated for age, sex, hypertension, degree of edema, degree of hematuria, proteinuria level, cholesterol level, albumin level, urea level, and creatinine level. Data were analyzed by using chi-square, fisher's exact test Mann Whitney analysis, multivariate by logistic multiple regression analysis, and diagnostic test. Results: Of the 36 subjects enrolled, 10 (27.8%) had MCNS, and 26 (72.2%) had NMCNS. Bivariate analysis showed significant differences in hypertension (p=0.020; OR=12.3; 95% CI 1.35-111.61) and hematuria (p=0.018; OR=7.7 ; 95% CI 1.52-39.75). Multivariate analysis indicated that only hematuria is a significant predictor (p=0.014; OR=7.778; 95% CI 1.522 – 39.754). The diagnostic test of NMCNS showed hematuria sensitivity at 77% and specificity at 70% with a positive predictive value of 87% and a negative predictive value of 46%. Conclusion: Our study showed that hematuria is a sensitive predictor of NMCNS.
Analisis Hubungan Antara Asupan Protein dengan Kejadian Stunting pada Balita di Puskesmas Lapai Alfian Fajri R; Hermiaty Nasruddin; Sigit Dwi Pramono; Muh. Alfian Jafar; Sidrah Darma
Green Medical Journal Vol 6 No 2 (2024): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v6i2.161

Abstract

Introduction: Stunting is a short stature caused by chronic malnutrition based on weight-for-age, height-for-age, and chronological age that greatly impacts child growth and development. According to SSGI 2021, Southeast Sulawesi is ranked fifth in Indonesia with the highest stunting rate at 30.2% and North Kolaka Regency has a stunting rate of 29.1%. The causes of stunting are quite diverse, one of which is the lack of protein food consumption. The purpose of this study was to determine the relationship between protein intake and the incidence of stunting in toddlers. Methods: This study was an observational analytic study. This study was participated by 18 children who were registered at the Lapai Health Centre. Using the cross-sectional method and chi-square test, 18 children will be analyzed to determine the relationship of protein intake to stunting. Results: The results showed that the percentage of toddlers with less protein intake was 72.2% and only 27.8% were in the sufficient category. Toddlers with the stunting category were 77.8% and toddlers with the normal category were only 22.2%. With data analysis using the chi-square test, the P-value <0.05 (P-value 0.04) was obtained. Conclusion: This study focuses on the increasing incidence of stunting in toddlers caused by a lack of protein intake. The results of this study emphasize to that parents and local governments to pay more attention to children's protein intake during toddlerhood by providing varied protein intake.
Co-Authors Alfian Fajri R Dasril Daud Hermiaty Nasruddin Sidrah Darma Sigit Dwi Pramono Syarifuddin Rauf