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All Journal Green Medical Journal Muhammadiyah Medical Journal
Andi Sitti Fahirah Arsal
Department of Pharmacology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Antibacterial Potency of Black Garlic Extract from Allium sativum on Escherichia coli Muhammad Alief Harun; Sultan Buraena; Eny Arlini Wello; Hasta Handayani Idrus; Andi Sitti Fahirah Arsal
Green Medical Journal Vol 3 No 3 (2021): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v3i3.92

Abstract

Background: Diarrhea is still one of the global issues especially in developing countries. Diarrhea can be caused by either an infectious agent or a non-infectious agent. Escherichia coli is one of the infectious agents that is responsible for causing diarrhea. Garlic (Allium sativum) is a plant that has a good antibacterial activity potential because of its organosulfur and phenolic compound. Black garlic is the product of spontaneous fermentation of garlic that has improved its bioactive compounds. Content: Antibacterial potency of black garlic extract on Escherichia coli is shown on the resistance zone that formed where the lowest zone diameter is 9,67 mm while the highest zone is 24 mm. The fermentation of black garlic happened at the temperature of 70-80°C with 75-80% for 28-40 days. Conclusion: Black garlic is shown to exhibit antibacterial activity against bacteria such as Escherichia coli. This fermented product has the potential to be a therapeutic agent for diseases caused by Escherichia coli.
Antihypertensive Effects of Allium sativum Extract in Epinephrine-Induced Hypertensive Wistar Rats Nurul Hikmah A. Muthalib; Zulfitriani Murfat; Dian Fahmi Utami; Wisudawan; Andi Sitti Fahirah Arsal
Muhammadiyah Medical Journal Vol. 7 No. 2 (2026): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.7.2.26-36

Abstract

Background: Hypertension remains a major cardiovascular disorder and continues to contribute substantially to morbidity and mortality. Garlic, or Allium sativum, has been widely studied as a natural agent with potential antihypertensive effects due to its bioactive sulfur compounds and vascular protective properties. Purpose: This study aimed to determine the antihypertensive effect of Allium sativum extract in epinephrine-induced hypertensive Wistar rats and to compare its effect at different dose levels. Methods: This study employed a true experimental pretest-posttest control group design. A total of 20 male Wistar rats were divided into five groups: three treatment groups receiving Allium sativum extract at doses of 50 mg, 100 mg, and 200 mg; one negative control group; and one positive control group receiving amlodipine. Blood pressure was measured before induction, after epinephrine induction, and after treatment. Data were analyzed using a paired-samples t-test and one-way ANOVA. Results: Epinephrine significantly increased systolic and diastolic blood pressure in all groups. After treatment, blood pressure decreased in the extract-treated groups. The 200 mg group showed the greatest mean systolic reduction of 60.50 mmHg (approximately a 33.9% decrease from post-induction values) and a mean diastolic reduction of 39.00 mmHg (approximately a 31.8% decrease). One-way ANOVA showed no significant differences between groups at pretest (p=0.523 systolic; p=0.085 diastolic), while significant differences were found at posttest (p=0.000 for both). Post hoc analysis confirmed that the 200 mg group produced the strongest antihypertensive effect among all tested groups. Conclusion: Allium sativum extract demonstrated significant antihypertensive activity in an epinephrine-induced hypertension model. The 200 mg dose produced the most pronounced reduction in blood pressure (systolic: ~33.9%; diastolic: ~31.8%), establishing a clear dose-response relationship.
Co-Authors Dian Fahmi Utami Eny Arlini Wello Hasta Handayani Idrus Muhammad Alief Harun Nurul Hikmah A. Muthalib Sultan Buraena Wisudawan Zulfitriani Murfat