Burnout is a psychological syndrome arising from prolonged occupational stress, characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment. This condition not only affects psychological well-being but also has significant implications for neural functioning, particularly in cognition and emotional regulation. This study aims to systematically examine neurophysiological changes associated with burnout through recent neuroimaging research, specifically those utilizing electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). A literature search was conducted across four major databases—PubMed, Scopus, PlosOne, and ScienceDirect—resulting in the selection of eight studies that met predefined inclusion criteria. Findings indicate that individuals experiencing burnout exhibit alterations in various EEG components, such as reduced P300 and Pe amplitudes, and changes in N200 and MMN responses. These patterns suggest impairments in information processing, decision-making, and error awareness. fMRI studies further reveal decreased activation in prefrontal brain regions, including the dorsolateral prefrontal cortex (DLPFC) and middle frontal gyrus (MFG), which are critical for executive functions and emotional regulation. Overall, burnout appears to involve complex dysfunctions in central nervous system activity, disrupting both cognitive and emotional responses. These insights underscore the need for a neuropsychological approach to burnout detection and intervention. Moreover, neuroimaging findings may serve as a foundation for developing early, evidence-based strategies aimed at promoting mental well-being in occupational settings.