Background: Creating good and quality health services is inseparable from the performance of health workers which can affect the level of patient satisfaction. This study aims to determine the influence of perceived leadership, job satisfaction, and work environment on the performance of health workers at dr. Soediran Mangun Sumarso Hospital. Subjects and Method: The study was conducted with a cross-sectional study design. The approach used was an analytical observational model with a sample size of 200 health workers. This study was conducted at dr. Soediran Mangun Sumarso Hospital, Wonogiri Regency in November-December 2023. A sample of 200 health workers was selected using stratified random sampling. The dependent variable in this study was the performance of health workers. Meanwhile, the independent variables in this study were perceived leadership, job satisfaction, work environment, age, and length of working. Data collection was carried out using questionnaires, and the data were analyzed using a double linear regression analysis model. Results: Each 1 unit increase in the leadership score would be followed by an increase in performance score (b= 0.33; CI 95%= 0.21 to 0.45; p<0.001), job satisfaction (b= 0.14; CI 95%= 0.06 to 0.21; p<0.001), work environment (b= 0.26; CI 95%= 0.06 to 0.46; p=0.010), age ≥37 years (b= 0.19; CI 95%= -0.90 to 1.29; p=0.728), length of working ≥10 years (b= 0.94; CI 95%= -0.16 to 2.04; p=0.093). Conclusion: There is an influence of leadership, job satisfaction, work environment, age, and length of working on the performance of health workers at Dr. Soediran Mangun Sumarso Hospital, Wonogiri.