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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Putri Margaretha Glaudy Pani
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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GRANUL EKSTRAK DAGING BUAH PALA SEBAGAI SUPLEMEN IMUNOMODULATOR YANG DIUJI SECARA IN VITRO Putri Margaretha Glaudy Pani; Amanda Putri Pratikto; I Dewa Ayu Accyuta Kirana; Tamariska Putri Pratikto; Brigitte Dominique Lalujan; Jelly Angelia; Julianri Sari Lebang
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 1 (2025)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i1.58439

Abstract

Nutmeg fruit flesh contains secondary metabolites that are beneficial to health. The secondary metabolites contained in nutmeg fruit flesh are flavonoids and alkaloids. This study aimed to formulate nutmeg fruit flesh extract into granules as an immunomodulatory supplement and test its phagocytosis activity in vitro. The methods used include the extraction of nutmeg fruit flesh using 70% ethanol maceration, granule formulation with three variations of extract concentration (10%, 15%, 20%), in vitro testing of macrophage phagocytosis activity, and evaluation of the granule formulation. The results showed that the test solution with a 20% concentration exhibited a high phagocytosis value of 69.01%. Increasing the extract concentration resulted in increased phagocytosis activity values, indicating that the immunomodulatory effect of the extract stimulates macrophage cells to phagocytose the test bacterial cells. Therefore, it can be concluded that nutmeg fruit extract granules can serve as an immunomodulatory supplement to enhance the immune system.
Co-Authors Amanda Putri Pratikto Brigitte Dominique Lalujan I Dewa Ayu Accyuta Kirana Jelly Angelia Julianri Sari Lebang Tamariska Putri Pratikto