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All Journal Journal of Community and Clinical Pharmaceutical Sciences
R.F Yustisia
Universitas Muhammadiyah Mataram

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Exploration of Ethnomedicinal Plants for Skin Diseases: A Network Pharmacology Approach to Revealing the Molecular Mechanisms of Traditional Herbs R.F Yustisia; Risdayanti Risdayanti; R.A. Mauliantari
Journal of Community and Clinical Pharmaceutical Sciences Vol. 1 No. 1 (2026): May
Publisher : Visi Pencerah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64581/jccps.v1i1.100

Abstract

Improvement prevalence disease skin multifactorial and limitations therapy conventional push exploration Ethnomedicine uses a systems approach to discover more effective and safe drug candidates. This study aims to analyze and synthesize scientific evidence related to the use of ethnomedicinal plants in the treatment of skin diseases and identify the relationship between ethnomedicine and drug use. between bioactive compounds with target biological through a network pharmacology approach . The method used is qualitative research with an integrative review approach , using data sources from Google Scholar, Elicit, Scite.ai, Scispace, DOAJ, and Scopus, with the inclusion criteria of articles from 2016–2026, relevant, speaking English Indonesian, And available full-text . The results of the study indicate that plants with high ethnobotanical value contain secondary metabolites such as flavonoids, alkaloids, and terpenoids that contribute to antioxidant, antimicrobial, and anti-inflammatory activities. The network pharmacology approach reveals multi-target interactions through biological pathways such as inflammation, apoptosis, and metabolism, which are strengthened by bioinformatics and molecular docking analysis . The conclusion of this study confirms that the integration of ethnomedicine and network pharmacology is able to explain comprehensive molecular mechanisms of medicinal plants. The implementation has the potential support development drug evidence-based herbal scientific and become the basis for innovation in modern dermatological therapy.
Co-Authors R.A. Mauliantari Risdayanti Risdayanti