This st This study aims to explain the role of teachers integrating deep learning and differentiation for meaningful learning in school learning. The research method uses library research. Data were collected through literature search techniques and analyzed using a qualitative approach with content analysis to produce a comprehensive and systematic overview of the themes studied. The main source of this study used Google Scholar. Sources can be journals, books, dictionaries, documents, magazines, and other related sources. The results of this study are: The application of deep learning focuses on deep conceptual understanding and critical thinking, not just memorizing material. Then, the strategy of integrating differentiation in facilitating learning diversity of needs, interests, and learning styles of students so that the learning process can run in depth in an inclusive and optimal manner. The application of deep learning strategies can foster student interest in learning, which can be done by using a deep learning approach according to the material that has been explained. The concept of deep learning has a strategic role in improving the quality of education by encouraging deeper conceptual understanding, critical thinking skills, and problem-solving abilities among students. The integration of deep learning in the educational curriculum shows that this approach not only improves academic outcomes but also forms a more analytical and innovative mindset. The evaluation results, using performance tasks, successfully shifted the traditional assessment paradigm (multiple-choice) to one that realistically tested students' analytical, synthetic, and innovative abilities.