The increasing prevalence of chronic kidney disease requiring hemodialysis highlights the importance of understanding patients’ experiences in maintaining quality of life during long-term treatment. Hemodialysis imposes substantial physical, psychological, social, and spiritual challenges that require continuous adaptation. This study aimed to explore the lived experiences of hemodialysis patients in maintaining quality of life. A qualitative study with a phenomenological approach was conducted involving 13 hemodialysis patients selected through purposive sampling. Data were collected through in-depth interviews and analyzed using Interpretative Phenomenological Analysis (IPA). Trustworthiness was ensured through member checking and systematic thematic interpretation. Three major themes emerged: (i) lived experiences and changes in the meaning of life, including initial reactions of shock, fear, denial, and eventual acceptance of hemodialysis; (ii) coping strategies and social support during treatment, encompassing personal coping mechanisms, family and social support, and spirituality as a source of resilience; and (iii) perceptions of quality of life and future expectations, highlighting subjective interpretations of well-being and aspirations to remain healthy, independent, and meaningful in daily life. The findings revealed that hemodialysis patients sustained their quality of life through a dynamic process of adaptation. This process involved managing physical challenges, developing psychological resilience, maintaining supportive social relationships, and strengthening spiritual beliefs, all of which contributed to their overall well-being.