Atika Nirmala
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Nahdlatul Ulama Sunan Giri

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Evaluasi potensi antioksidan sediaan toner kombinasi lidah buaya (Aloe vera L.) dan daun kemangi (Ocimum basilicum L.) Shofiatin Hanafi; Yani' Qoriati; Atika Nirmala
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3817

Abstract

Background: Natural antioxidants are widely developed in cosmetic preparations because they can protect the skin from oxidative stress caused by free radicals. Aloe vera gel and Ocimum basilicum leaf extract contain flavonoids. phenolic compounds. and other bioactive constituents with antioxidant potential. making them promising active ingredients for facial toner formulations. Purpose: To determine the optimal formulation for a toner combining aloe vera gel and basil leaf extract. based on physical quality and antioxidant activity using the DPPH method. Method: This true experimental study employed a Completely Randomized Design (CRD) with six formulations (F0-F5) differing in the ratio of Aloe vera gel and Ocimum basilicum leaf extract. Physical quality evaluation included organoleptic properties. pH. homogeneity. viscosity. and hedonic testing. Antioxidant activity was determined using the DPPH method and expressed as IC₅₀ values. Data were analyzed using One-Way ANOVA followed by the Games-Howell post hoc test with a significance level of p<0.05. Results: All formulations met the physical quality requirements. showing good organoleptic characteristics. homogeneous appearance. pH of 6.0. and viscosity ranging from 0.91-1.18 cP. Hedonic evaluation indicated good acceptance. with F1 being the most preferred formulation. Antioxidant testing demonstrated significant differences among formulations (p<0.05). Formulation F2 exhibited the strongest antioxidant activity with an IC₅₀ value of 22.80 ± 0.03 ppm. classified as a very strong antioxidant. Conclusion: The combination of Aloe vera gel and Ocimum basilicum leaf extract can be successfully formulated into a facial toner with acceptable physical quality and very strong antioxidant activity. Formulation F2 was identified as the optimum formulation based on its antioxidant performance.   Keywords: Aloe vera; Antioxidant Activity; DPPH; Facial Toner; Ocimum basilicum.