Faradillah Puspitasari
Program Studi S1 Kedokteran Universitas Malahayati

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Hubungan derajat hipertensi dengan lokasi perdarahan intrakranial pada pasien stroke hemoragik Faradillah Puspitasari; Boby Suryawan; Akhmad Kheru Dharmawan; Sariningsih Sariningsih
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 5 (2026): September edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i5.4160

Abstract

Background: Hemorrhagic stroke is one of the leading causes of mortality and disability resulting from intracranial hemorrhage. Hypertension is the most important modifiable risk factor that contributes to structural changes in cerebral blood vessels, thereby increasing the risk of intracranial hemorrhage. The severity of hypertension is suspected to be associated with the location of intracranial hemorrhage identified by Computed Tomography (CT) scan. Purpose: To determine the relationship between the severity of hypertension and the location of intracranial hemorrhage in patients with hemorrhagic stroke. Method: This observational analytic study employed a cross-sectional approach with a retrospective design. A total of 62 patients with hemorrhagic stroke who met the inclusion and exclusion criteria were included using a total sampling technique. Data on hypertension severity and intracranial hemorrhage location were obtained from medical records. Univariate analysis was performed to describe the characteristics of the variables, while the relationship between variables was analyzed using Fisher's Exact test with a significance level of p<0.05. Results: Most patients had grade III hypertension (51.6%), while the most frequent location of intracranial hemorrhage was the basal ganglia/putamen (40.3%). Among patients with grade III hypertension, hemorrhage predominantly occurred in the basal ganglia/putamen (56.3%). Fisher's Exact test demonstrated a statistically significant relationship between the severity of hypertension and the location of intracranial hemorrhage (p=0.002). Conclusion: The severity of hypertension is significantly associated with the location of intracranial hemorrhage in patients with hemorrhagic stroke. Higher grades of hypertension tend to be associated with hemorrhage occurring in deep brain structures, particularly the basal ganglia/putamen.   Keywords: Computed Tomography (CT) Scan; Hemorrhagic Stroke; Hypertension Severity; Intracranial Hemorrhage Location.