<![CDATA[Background: Anemia is a global health problem affecting over 1.62 billion people worldwide. In Indonesia, the prevalence of anemia among pregnant women reaches 48.9%. A 2022 survey by the Indonesian Ministry of Health showed that only 30% of prospective brides and grooms had adequate knowledge about anemia and its impact on reproductive health. Objective: To analyze the relationship between the level of knowledge of prospective brides and grooms about anemia and compliance with consuming Fe tablets in the DKI Jakarta area. Methods: A quantitative cross-sectional study was conducted on 30 prospective brides and grooms selected using purposive sampling technique. The inclusion criteria were 20-35 years old, never experienced severe anemia, and had access to health education programs on anemia. Data were collected using a structured questionnaire that had been tested for validity and reliability. Data were analyzed using univariate and bivariate analysis with the Chi-Square test at a significance level of α = 0.05. Results: The majority of respondents were aged 20-35 years (70.0%), had a high school education (40.0%), and worked as housewives (40.0%). The level of knowledge of respondents showed a good category of 46.7%, sufficient 33.3%, and less than 20.0%. Compliance with consumption of Fe tablets showed 60.0% compliant and 40.0% non-compliant. The results of the Chi-Square test showed a p-value = 0.007 (p < 0.05), which means there is a significant relationship between the level of knowledge about anemia and compliance with consumption of Fe tablets. Respondents with good knowledge had high compliance (85.7%), sufficient knowledge had 50.0% compliance, while only 16.7% were compliant with poor knowledge. Conclusion: There was a significant relationship between the level of knowledge of anemia among prospective brides and grooms and grooms and their adherence to iron tablet consumption (p = 0.007). It is recommended to improve systematic and sustainable health education programs, develop technology-based monitoring systems, involve couples and families in educational programs, and provide comprehensive counseling on managing the side effects of iron tablets]]>
