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All Journal Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Ahmad Mubin Hutasuhut
Graha Hermine Hospital
Dentistry Health Professions Public Health

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Clinical Efficacy of Nigella sativa-Containing Interventions for Urolithiasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Kamal Fariz; Ahmad Mubin Hutasuhut
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 4 No. 4 (2026): Oktober: Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v4i4.6909

Abstract

Introduction: Urolithiasis is common, and reviews suggest benefits of N. sativa, although evidence remains limited. This review evaluated efficacy and safety of N. sativa-based interventions in adults with urinary stones. Method: The protocol was registered in PROSPERO (CRD420261470368). PubMed, Scopus, ScienceDirect, and Google Scholar were searched to 3 August 2026. Randomized controlled trials of N. sativa-based interventions were eligible, with risk of bias assessed using the Cochrane Risk of Bias 2 tool. Result: Four trials involving 262 participants were included. Compared with tamsulosin, N. sativa-containing interventions increased complete stone passage (RR = 2.12, 95% CI: 1.31–3.43; p = 0.002; I² = 0%). Compared with control or placebo, N. sativa-based interventions increased stone passage (RR = 2.47, 95% CI: 1.50–4.08; p = 0.0004; I² = 0%). Stone size reduction favored N. sativa-based interventions (MD = −2.32 mm, 95% CI: −3.07 to −1.57; p < 0.00001; I² = 0%). Each meta-analysis included only two trials. One study had low risk of bias and three had some concerns. Safety data were limited. Conclusion: N. sativa-based interventions may improve stone passage and reduce stone size, but evidence is limited by few trials, heterogeneous interventions, and safety reporting. Larger trials using standardized preparations are needed.
In Vitro Anticancer Activity of Honey-Based Preparations Against Prostate Cancer Cells: A Systematic Review Kamal Fariz; Ahmad Mubin Hutasuhut
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 3 (2026): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i3.13065

Abstract

Introduction: Honey and honey-based preparations have attracted interest as potential sources of anticancer compounds, but evidence in prostate cancer remains heterogeneous. This systematic review aimed to synthesize and critically appraise in vitro evidence of honey-based preparations against human prostate cancer cells. Methods: PubMed, Scopus, and ScienceDirect were searched on 19 August 2026 without publication-year restrictions. Primary in vitro studies evaluating whole honey, crude honey extracts, or honey-based preparations in human prostate cancer cell lines were included. Methodological reliability was assessed using the 18-criterion Toxicological data Reliability Assessment Tool (ToxRTool). Results: Seven studies were included, primarily involving PC-3 and, in some studies, DU145 cells. Outcomes included cell viability, cytotoxicity, proliferation, cell-cycle progression, migration, invasion, adhesion, and molecular or inflammatory endpoints. Honey-based preparations showed inhibitory effects, although findings varied by honey type, preparation, concentration, exposure duration, cell line, and assay methodology. Six studies were classified as ToxRTool Category III and one as Category I. Conclusion: Honey-based preparations may have anticancer potential against human prostate cancer cells in vitro, but evidence remains limited by substantial heterogeneity, methodological limitations, and potential assay interference. Further standardized and well-controlled studies are needed before in vivo and clinical investigation.
Co-Authors Kamal Fariz