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All Journal Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Ferianto Ferianto
Universitas Abdurrab
Health Professions Nursing Public Health

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Efek Kava (Piper Methysticum) Sebagai Anestesi Lasmaria Flora Roslinda Silaen; Matdhika Sakti; Ferianto Ferianto
Jurnal Ventilator Vol. 3 No. 1 (2025): Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v3i1.1737

Abstract

Kava (Piper Methysticum) is a plant traditionally used in the South Pacific for its sedative and anxiolytic effects. Its active compounds, kavalactones, are known to have potential as natural anesthetics, with a mechanism of action similar to benzodiazepines and general anesthetics. This study aims to evaluate the effectiveness of Kava as an anesthetic through a systematic literature review and meta-analysis. Literature searches were conducted in PubMed, Scopus, and Cochrane Library using relevant keywords. Meta-analysis results indicate that Kava significantly enhances anesthetic effects compared to placebo, primarily through modulation of GABA-A receptors. However, further research is needed to determine the optimal dosage and long-term safety.
Co-Authors Lasmaria Flora Roslinda Silaen Matdhika Sakti